Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses.
نویسندگان
چکیده
The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.
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عنوان ژورنال:
- Journal of virology
دوره 77 22 شماره
صفحات -
تاریخ انتشار 2003